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Laboratory findings reveal the role of DarF in producing dehydrodarobactin A, indicating its significance in antibiotic synthesis.
Darobactin A is a potent antibiotic, but the biosynthesis of its derivative, dehydrodarobactin A, remains unclear. Here, we discovered HExxH enzyme DarF catalyzes a dehydrogenation-epoxidation reaction and linked to dehydrodarobactin A biosynthesis.
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Haedar et al. (2026) studied this question.
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