What question did this study set out to answer?

This study aims to develop a multilayered bioactive dental membrane that optimizes mechanical strength, biodegradability, and antibacterial properties.

May 22, 2026PharmaceuticsOpen Access

Development of a Bioactive Dental Barrier Membrane Based on PCL/Collagen and PVA/Hydroxyapatite Layers with Amoxicillin-Loaded Electrosprayed Coating

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Authors

HAHilal Gülsena Nur AkkusYıldız Technical University ABAyşe Betül BingölYıldız Technical University BOBüşra OktayYıldız Technical University

Discussion

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Implication

Randomized trial evaluates antibacterial and mechanical properties of a bioactive dental membrane, suggesting effective guided bone regeneration.

Key Points

This study aims to develop a multilayered bioactive dental membrane that optimizes mechanical strength, biodegradability, and antibacterial properties.
Fabricated a multilayered membrane using electrospinning and electrospraying techniques with PCL/Collagen and PVA/HAp layers.
Evaluated membrane with SEM, FTIR, EDS, tensile tests, swelling behavior, hydrolytic degradation, and in vitro drug release assessments.
Tested antibacterial activity against Staphylococcus aureus and Escherichia coli, and assessed cytocompatibility with L929 fibroblasts.
Membrane showed maximum tensile strength of 15.17 N and strain of 25.24%, with significant swelling at ~100% within 2 h.
Drug release profiles indicated rapid amoxicillin release in first 50 min, plateauing at 4.5 mg/L by 350 min.
The PCL/Col–PVA/Col/HAp–PVA/Amox group demonstrated cell viability of ~140% after 7 days, which was significantly higher than control groups (p < 0.01).

Cite This Study

Akkus et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff38cd674f7c03778c4f6 https://doi.org/10.3390/pharmaceutics18050610

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May 22, 2026PharmaceuticsOpen Access

Development of a Bioactive Dental Barrier Membrane Based on PCL/Collagen and PVA/Hydroxyapatite Layers with Amoxicillin-Loaded Electrosprayed Coating

View Full Paper

Ask AI

Bookmark

Authors

HAHilal Gülsena Nur AkkusYıldız Technical University ABAyşe Betül BingölYıldız Technical University BOBüşra OktayYıldız Technical University

Discussion

Member takes

Implication

Randomized trial evaluates antibacterial and mechanical properties of a bioactive dental membrane, suggesting effective guided bone regeneration.

Key Points

This study aims to develop a multilayered bioactive dental membrane that optimizes mechanical strength, biodegradability, and antibacterial properties.
Fabricated a multilayered membrane using electrospinning and electrospraying techniques with PCL/Collagen and PVA/HAp layers.
Evaluated membrane with SEM, FTIR, EDS, tensile tests, swelling behavior, hydrolytic degradation, and in vitro drug release assessments.
Tested antibacterial activity against Staphylococcus aureus and Escherichia coli, and assessed cytocompatibility with L929 fibroblasts.
Membrane showed maximum tensile strength of 15.17 N and strain of 25.24%, with significant swelling at ~100% within 2 h.
Drug release profiles indicated rapid amoxicillin release in first 50 min, plateauing at 4.5 mg/L by 350 min.
The PCL/Col–PVA/Col/HAp–PVA/Amox group demonstrated cell viability of ~140% after 7 days, which was significantly higher than control groups (p < 0.01).

Cite This Study

Akkus et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff38cd674f7c03778c4f6 https://doi.org/10.3390/pharmaceutics18050610

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