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May 22, 2026MoleculesOpen Access

miR-27a Suppresses Mitochondrial Function to Promote Hepatic Steatosis in High-Fat-Diet-Induced Obesity

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Authors

ZYZexin YuUnion HospitalXYXuehan YangJilin UniversityBSBo SunQingdao University

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Implication

Randomized trial reveals miR-27a's role in promoting hepatic steatosis in obesity, indicating potential therapeutic avenues.

Key Points

  • This study aims to elucidate the role of miR-27a in hepatic steatosis and its effects on mitochondrial function in obesity.
  • Utilized in vivo mouse models with high-fat diet-induced obesity and low-fat diet controls.
  • Conducted gain- and loss-of-function experiments regarding miR-27a in hepatocytes.
  • Performed in vitro assays using HepG2 cells to analyze miR-27a's effect on NFE2L2.
  • MiR-27a was significantly upregulated in obese mice's serum and liver, correlating with hepatic steatosis.
  • Overexpression of miR-27a led to mitochondrial dysfunction, evidenced by increased ROS and reduced biogenesis.
  • Silencing miR-27a improved mitochondrial function and reduced lipid accumulation, confirming its role.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3d9d674f7c03778cb9ahttps://doi.org/10.3390/molecules31101753
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