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July 29, 2025Open Access

Combined Deletion of miR-27a and miR-27b Enhances Protection Against Diet-Induced Obesity

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Authors

DKDevesh KesharwaniMKMichele KarolakCDChad C. Doucette

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Overview

Combined deletion enhances thermogenesis and metabolic health in mice with diet-induced obesity, suggesting new therapeutic targets.

Key Points

  • Combined deletion of mir-27a and mir-27b significantly improves thermogenesis in white adipose tissue.
  • Double knockout mice show enhanced Ucp1 expression and better glucose and insulin sensitivity than single knockouts.
  • A high-fat diet reduces thermogenic gene expression while increasing mir-27a/b levels in adipose tissue.
  • Targeting miR-27a and miR-27b could provide a novel approach to treat obesity-related metabolic issues.

Cite This Study

Kesharwani et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cebd6https://doi.org/10.1101/2025.07.21.666011
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  4. 4miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in Mice2025
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