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December 12, 2025Diabetes

miR-494 Deletion Improves Glucose Metabolism Independently of Obesity in Mice

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Authors

LSLucia SugawaraKMKatsutaro MorinoHIHirotaka Iwasaki

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Overview

Ko mice improved glucose tolerance and reduced obesity risk, suggesting targeting miR-494 may aid metabolic health.

Key Points

  • This research examines the role of miR-494 deletion on glucose metabolism and obesity in mice.
  • Genetic deletion of miR-494 using CRISPR/Cas9 in mice
  • Assessment of browning in white adipose tissue
  • Analysis of glucose tolerance under normal chow and high-fat diet conditions
  • Metabolomic and Seahorse analyses for metabolic assessment
  • miR-494 knockout mice displayed increased browning of white adipose tissue
  • KO mice showed improved glucose tolerance even without weight loss
  • Enhanced oxidative phosphorylation linked to miR-494 deletion
  • Low miR-494 expression associated with better glucose tolerance in human adipose tissue data

Cite This Study

Sugawara et al. (2025) studied this question.

synapsesocial.com/papers/694019192d562116f28f652fhttps://doi.org/10.2337/db25-0355
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