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May 22, 2026Journal of Translational MedicineOpen Access

Interferon-induced protein 44-like promoter Hypomethylation as an epigenetic hallmark of systemic lupus erythematosus

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Authors

XZXiaohui ZhangYFYong FanLJLanlan Ji

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Overview

Cross-sectional study evaluates IFI44L promoter hypomethylation as a biomarker for SLE diagnosis and monitoring, suggesting its clinical relevance.

Key Points

  • This study aims to investigate IFI44L promoter methylation dynamics and its potential as a diagnostic and monitoring biomarker in systemic lupus erythematosus.
  • Cross-sectional study with a longitudinal component including 566 participants across different disease stages.
  • Methylation quantified using high-resolution melting analysis; differences between groups analyzed using non-parametric tests.
  • ROC curves and correlation tests assessed diagnostic performance and clinical associations.
  • IFI44L promoter methylation levels decreased progressively from healthy controls to active SLE, with hypomethylation observed in 90.5% of treatment-naïve SLE patients.
  • The diagnostic accuracy for distinguishing SLE from healthy controls was high (AUC 0.892; sensitivity 78.5%, specificity 100%).
  • Longitudinal analysis showed significant increases in IFI44L methylation following treatment induction (p = 0.018).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ffd674f7c03778cf75https://doi.org/10.1186/s12967-026-08282-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IFI44L promoter hypomethylation as an epigenetic biomarker of systemic lupus erythematosus: A systematic review and meta-analysis2026
  2. 2DNA methylation of IFI44L as a potential blood biomarker for childhood-onset systemic lupus erythematosus2024 · 17 citations
  3. 3A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus2026 · 1 citations
  4. 4DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity2025
  5. 5Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance2025 · 5 citations