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August 22, 2026Lupus

IFI44L promoter hypomethylation as an epigenetic biomarker of systemic lupus erythematosus: A systematic review and meta-analysis

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Authors

KSKainat SherazAFAasiyah FagboRSRahemeen Siddique

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Overview

Systematic review and meta-analysis demonstrates consistent IFI44L promoter hypomethylation in systemic lupus erythematosus, indicating its viability as a diagnostic epigenetic biomarker.

Key Points

  • To systematically assess evidence on IFI44L promoter methylation in systemic lupus erythematosus (SLE) and quantitatively evaluate its diagnostic accuracy across diverse patient populations.
  • Conducted a systematic literature search to extract IFI44L promoter methylation profiles, ethnicity, cell types, and CpG methylation direction in SLE cases versus controls across 16 study datasets.
  • Applied random-effects meta-analysis (DerSimonian–Laird) with Hanley-McNeil variance approximation to determine the pooled area under the receiver operating characteristic curve (AUC).
  • IFI44L promoter hypomethylation predominated over hypermethylation and was consistently observed across ethnic groups and biological sample types across all 16 datasets.
  • The pooled area under the curve (AUC) for IFI44L hypomethylation was 0.74 (95% CI 0.64–0.84), demonstrating moderate overall diagnostic performance that remained largely independent of sample size.

Cite This Study

Sheraz et al. (2026) studied this question.

synapsesocial.com/papers/6a895fc4ca7ade938187ea90https://doi.org/10.1177/09612033261479099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interferon-induced protein 44-like promoter Hypomethylation as an epigenetic hallmark of systemic lupus erythematosus2026
  2. 2DNA methylation of IFI44L as a potential blood biomarker for childhood-onset systemic lupus erythematosus2024 · 17 citations
  3. 3Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance2025 · 5 citations
  4. 4DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity2025
  5. 5Epigenome-wide DNA methylation patterns associated with disease activity in systemic lupus erythematosus2026 · 1 citations