What question did this study set out to answer?

This research aims to understand the role of the PGD2/DP2 axis in basophil activation and its implications for asthma.

May 22, 2026Communications BiologyOpen Access

The PGD2/DP2 axis promotes pro-inflammatory responses but attenuates an antigen-presenting role of human basophils

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Randomized trial investigates PGD2/DP2 impact on inflammation and antigen-presentation in basophils, suggesting therapeutic targets for asthma.

This research aims to understand the role of the PGD2/DP2 axis in basophil activation and its implications for asthma.
Exploration of PGD2/DP2 stimulation in human basophils
RNA sequencing to analyze gene transcriptional signatures
In vitro experiments to evaluate basophil activation and cytokine production
PGD2/DP2 stimulation enhances basophil recruitment and type 2 cytokine production
PGD2 downregulates MR1, reducing antigen-presentation to MAIT cells and IFN-γ production
Evidence suggests PGD2/DP2 as a contributor to asthma, particularly under low IgE conditions

Luo et al. (2026) studied this question.

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Randomized trial investigates PGD2/DP2 impact on inflammation and antigen-presentation in basophils, suggesting therapeutic targets for asthma.