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September 1, 2023Mayo Clinic ProceedingsOpen Access

Exercise Test Predicts Both Noncardiovascular and Cardiovascular Death in a Primary Prevention Population

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Why the study?

To identify specific causes of death, determine the prevalence of non-CV deaths in an exercise test referral population, and test whether exercise test parameters predict non-CV as well as CV deaths.

Do exercise test abnormalities predict non-cardiovascular and cardiovascular death in a primary prevention population?

Population

13,382 patients aged 30 to 79 years without baseline CV diseases

Comparison

Exercise test abnormalities vs normal parameters

Design

Retrospective cohort study

Follow-up

12.7±5.0 years

Authors

NSNóra SydóPreventive CardiologyUIUmair IftikharMayo ClinicECEmese CsulakCardiac Imaging

Discussion

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Member takes

Overview

May warrant inclusion in broader risk assessment; extends prior associations to non-CV mortality but leaves open need for interventional trials.

Structured PICO

Do exercise test abnormalities predict non-cardiovascular and cardiovascular death in a primary prevention population?

P
Population
13,382 patients aged 30 to 79 years without baseline cardiovascular diseases (primary prevention cohort), Minnesota residents, mean age 50.5, 35.4% female.
I
Intervention
Non-imaging exercise testing assessing functional aerobic capacity, heart rate recovery, chronotropic index, and exercise ECG
O
Outcome
Non-cardiovascular and cardiovascular death at 12.7±5.0 years follow-uphard clinical

Exercise test abnormalities, such as low functional aerobic capacity and abnormal heart rate recovery, predict both cardiovascular and non-cardiovascular mortality in a primary prevention population.

Cite This Study

Sydó et al. (2023) studied this question.

synapsesocial.com/papers/6a0ff59b57bfcc72645fc7cdhttps://doi.org/10.1016/j.mayocp.2023.05.029

Topics

Cardiovascular preventionWomen and heart diseaseHypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Performance of Heart Rate Recovery on an Exercise Test in a Primary Prevention Population2018 · 45 citations
  2. 2Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function2011 · 116 citations
  3. 3Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis2021 · 107 citations
  4. 4Exercise Capacity and the Risk of Death in Women2003 · 744 citations
  5. 5Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association2022 · 6,165 citations