Key result
Continuous positive airway pressure therapy improved vagal heart rate control in OSA patients, with G(RSA) increasing directly with average nightly CPAP compliance in supine posture (p<0.01).
Why the study?
Does continuous positive airway pressure (CPAP) improve cardiac autonomic function in patients with moderate-to-severe obstructive sleep apnea?
Population
13 awake patients with moderate-to-severe obstructive sleep apnea (OSA)
Comparison
Continuous positive airway pressure home therapy… vs Baseline (before therapy)
Design
Cohort
Follow-up
3 to 9 months
Authors
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CPAP adherence may enhance vagal tone in OSA; hypothesis-generating and requires RCT confirmation before practice change.
Observational (n=13)
Does continuous positive airway pressure (CPAP) improve cardiac autonomic function in patients with moderate-to-severe obstructive sleep apnea?
p-value: p=<0.01
CPAP treatment improves vagal heart rate control in patients with OSA, with the degree of improvement varying directly with compliance level.
Khoo et al. (2001) conducted an observational in moderate-to-severe obstructive sleep apnea (OSA) (n=13). continuous positive airway pressure (CPAP) vs. Baseline (before therapy) was evaluated on cardiac autonomic function (G(RSA) and MLHR) (p=<0.01). Continuous positive airway pressure therapy improved vagal heart rate control in OSA patients, with G(RSA) increasing directly with average nightly CPAP compliance in supine posture (p<0.01).
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