Key result
Acute CPAP titration is linked to reduced HRV parameters in moderate to severe OSA.
Why the study?
Autonomic dysregulation is associated with cardiovascular consequences in OSA, prompting investigation into the effect of acute CPAP treatment on autonomic activity and factors contributing to HRV changes.
Does acute CPAP treatment improve heart rate variability in patients with moderate to severe obstructive sleep apnea?
Observational (n=402)
Does acute CPAP treatment improve heart rate variability in patients with moderate to severe obstructive sleep apnea?
Acute CPAP titration significantly alters heart rate variability parameters, suggesting a beneficial effect in restoring autonomic balance in patients with moderate to severe OSA.
Acute CPAP may modulate autonomic balance in moderate-severe OSA; leaves open whether this improves clinical outcomes.
Autonomic dysregulation is associated with cardiovascular consequences in obstructive sleep apnea (OSA). This study aimed to investigate the effect of acute continuous positive airway pressure (CPAP) treatment on autonomic activity and to identify factors contributing to heart rate variability (HRV) changes in OSA. Frequency domain HRV parameters were calculated and compared between the baseline polysomnography and during the CPAP titration in 402 patients with moderate to severe OSA. There were significant reductions in total power, very low-frequency band power, low-frequency band power, and high-frequency band power during the CPAP titration as compared to the baseline polysomnography. This tendency was pronounced in male patients with severe OSA. Multivariate analysis found that changes in the apnea-hypopnea index and oxygen saturation were significantly associated with changes in sympathetic and parasympathetic activity, respectively. This study demonstrated that HRV parameters significantly changed during the CPAP titration, indicating a beneficial effect of CPAP in the restoration of sympathetic and parasympathetic hyperactivity in OSA. Prospective longitudinal studies should determine whether long-term CPAP treatment aids in maintaining the long-lasting improvement of the autonomic functions, thereby contributing to the prevention of cardiovascular and cerebrovascular diseases in patients with OSA.
No takes yet. Share an insight, caveat, or question.
Shin et al. (2023) conducted an observational in obstructive sleep apnea (n=402). continuous positive airway pressure (CPAP) vs. baseline polysomnography was evaluated on Frequency domain heart rate variability (HRV) parameters. Acute CPAP titration significantly reduced HRV parameters, including total and frequency band power, compared to baseline in 402 patients with moderate to severe obstructive sleep apnea.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: