Key result
Long-term nasal CPAP in patients with obstructive sleep apnea significantly reduced the asleep LF/HF ratio from 1.21 to 1.11 (P<0.001), indicating reduced cardiac sympathetic tone.
Why the study?
Does long-term nasal CPAP reduce cardiac sympathetic autonomic tone in patients with obstructive sleep apnoea?
Observational (n=14)
Does long-term nasal CPAP reduce cardiac sympathetic autonomic tone in patients with obstructive sleep apnoea?
p-value: p=<0.001
Long-term CPAP therapy in patients with obstructive sleep apnea significantly reduces cardiac sympathetic tone as measured by heart rate variability.
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CPAP may lower sympathetic tone in OSA; supports mechanistic benefit but leaves outcome impact open.
Roche et al. (1999) conducted an observational in Obstructive sleep apnoea (OSA) (n=14). Nasal continuous positive airway pressure (CPAP) was evaluated on Autonomic nervous system assessed by heart rate variability (HRV) parameters including LF, HF, and LF/HF ratio (p=<0.001). Long-term nasal CPAP in patients with obstructive sleep apnea significantly reduced the asleep LF/HF ratio from 1.21 to 1.11 (P<0.001), indicating reduced cardiac sympathetic tone.
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