Key result
Patients with uncomplicated falciparum malaria had significantly higher absolute monocyte counts (516-736 per ml) and iNOS mRNA expression compared to patients with severe and complicated malaria.
Why the study?
Are iNOS mRNA levels and monocyte counts associated with the severity of Plasmodium falciparum malaria?
Observational (n=36)
No
Are iNOS mRNA levels and monocyte counts associated with the severity of Plasmodium falciparum malaria?
p-value: p=<0.001
High levels of iNOS mRNA and increased monocyte counts are associated with uncomplicated malaria, suggesting nitric oxide may have a protective role in Plasmodium falciparum infection.
No takes yet. Share an insight, caveat, or question.
Suggests nitric oxide may protect against severe malaria but should not change practice; leaves open prospective trials of iNOS modulation.
Chiwakata et al. (2000) conducted an observational in Plasmodium falciparum malaria (n=36). Uncomplicated malaria vs. Severe and complicated malaria was evaluated on Absolute monocyte counts at presentation (p=<0.001). Patients with uncomplicated falciparum malaria had significantly higher absolute monocyte counts (516-736 per ml) and iNOS mRNA expression compared to patients with severe and complicated malaria.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: