Key result
Admission plasma RNI levels were higher in fatal severe malaria cases than survivors (45 vs 24.1 mumol/L; P=0.031), but this association was abolished after adjusting for plasma creatinine (P=0.96).
Why the study?
Are admission plasma reactive nitrogen intermediate levels associated with mortality in adults with severe malaria?
Population
152 Vietnamese adults with severe malaria
Design
Case-control
Authors
Loading...
Adjusted plasma RNI shows no independent link to mortality in severe malaria; leaves open NO's prognostic role pending prospective data.
Case-Control (n=152)
Are admission plasma reactive nitrogen intermediate levels associated with mortality in adults with severe malaria?
Absolute Event Rate: 45% vs 24.1%
p-value: p=0.031
Systemic generation of nitric oxide does not appear to play a pivotal role in the pathogenesis of severe or cerebral malaria in adults.
Taylor et al. (1998) conducted a case-control in Severe falciparum malaria (n=152). Fatal severe malaria vs. Survivors was evaluated on Median admission plasma reactive nitrogen intermediate (RNI) levels (mumol/L) (p=0.031). Admission plasma RNI levels were higher in fatal severe malaria cases than survivors (45 vs 24.1 mumol/L; P=0.031), but this association was abolished after adjusting for plasma creatinine (P=0.96).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: