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December 1, 1975American Journal of Epidemiology

Epidemiologic Studies of Coronary Heart Disease and Stroke in Japanese Men Living in Japan, Hawaii and California: Distribution of Biochemical Risk Factors1

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Why the study?

Are there differences in biochemical risk factors for coronary heart disease and stroke among Japanese men living in Japan, Hawaii, and California?

Population

Japanese men living in Japan, Hawaii and California

Design

Cross-sectional

Authors

MNMilton Z. NichamanIdaho State UniversityHHHoward B. HamiltonNational Institutes of HealthAKA KaganIBM (United States)

Discussion

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Implication

Suggests environmental influences on risk factors; hypothesis-generating and leaves causal and practice implications open.

Key Points

  • To evaluate and compare the distributions of biochemical risk factors for coronary heart disease and stroke among Japanese men living in Japan, Hawaii, and California.
  • Epidemiologic comparative study analyzing cohorts of Japanese men living across three geographic locations: Japan, Hawaii, and California.
  • Implemented standardized laboratory protocols to ensure cross-site comparability of serum cholesterol, glucose, uric acid, and triglycerides across age groups.
  • Across every age group examined, the mean, median, and percentile distributions of serum cholesterol, glucose, uric acid, and triglycerides were consistently lower among men residing in Japan than those in Hawaii and California.

Structured PICO

Are there differences in biochemical risk factors for coronary heart disease and stroke among Japanese men living in Japan, Hawaii, and California?

P
Population
Japanese men living in Japan, Hawaii and California
O
Outcome
Distributions of serum cholesterol, glucose, uric acid and triglyceridessurrogate

Japanese men living in Japan have lower levels of biochemical risk factors for coronary heart disease and stroke compared to those living in Hawaii and California, suggesting environmental or lifestyle influences.

Cite This Study

Nichaman et al. (1975) studied this question.

synapsesocial.com/papers/6a100c904fb650da4ffedbb7https://doi.org/10.1093/oxfordjournals.aje.a112187
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EPIDEMIOLOGIC STUDIES OF CORONARY HEART DISEASE AND STROKE IN JAPANESE MEN LIVING IN JAPAN, HAWAII AND CALIFORNIA: INTRODUCTION11975 · 132 citations
  2. 2EPIDEMIOLOGIC STUDIES OF CORONARY HEART DISEASE AND STROKE IN JAPANESE MEN LIVING IN JAPAN, HAWAII AND CALIFORNIA: PREVALENCE OF CORONARY AND HYPERTENSIVE HEART DISEASE AND ASSOCIATED RISK FACTORS11975 · 410 citations
  3. 3EPIDEMIOLOGIC STUDIES OF CORONARY HEART DISEASE AND STROKE IN JAPANESE MEN LIVING IN JAPAN, HAWAII AND CALIFORNIA: MORTALITY11975 · 221 citations
  4. 4EPIDEMIOLOGIC STUDIES OF CORONARY HEART DISEASE AND STROKE IN JAPANESE MEN LIVING IN JAPAN, HAWAII AND CALIFORNIA: BLOOD PRESSURE DISTRIBUTION11975 · 54 citations
  5. 5A COMPARISON OF THE 12-YEAR MORTALITY AND PREDICTIVE FACTORS OF CORONARY HEART DISEASE AMONG JAPANESE MEN IN JAPAN AND HAWAII1988 · 95 citations