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August 19, 2025American Journal of Preventive CardiologyOpen Access

Impact of smoking cessation on cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries

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Why the study?

The impact of smoking status and the potential benefits of smoking cessation in patients with MINOCA remain poorly understood.

Does smoking cessation reduce major adverse cardiovascular events in patients with myocardial infarction with nonobstructive coronary arteries?

Population

1179 patients with MINOCA

Comparison

Non- vs ex- vs current smokers, and persistent smokers vs quitters within 1 year after MI

Design

Prospective single-center cohort study

Follow-up

Median 41.7 months

Authors

SGSide GaoInterventional CardiologySHSizhuang HuangChinese Academy of Medical Sciences & Peking Union Medical CollegeXLXinming LiuNortheastern University

Discussion

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Implication

May support smoking cessation counseling in MINOCA; leaves open confirmation in randomized trials.

Structured PICO

Does smoking cessation reduce major adverse cardiovascular events in patients with myocardial infarction with nonobstructive coronary arteries?

P
Population
1179 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) from a Chinese cohort
I
Intervention
Smoking cessation (quitting within 1 year after MI)
C
Comparator
Persistent smoking (continued tobacco use within 1 year after MI)
O
Outcome
Major adverse cardiovascular events (MACE), a composite of death, nonfatal MI, stroke, revascularization, and hospitalization for unstable angina or heart failure at median 41.7 months follow-upcomposite

In patients with MINOCA, smoking cessation within 1 year after MI significantly reduces the risk of major adverse cardiovascular events compared to persistent smoking.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/6a100dfe92676d5461fd771ahttps://doi.org/10.1016/j.ajpc.2025.101080
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of smoking on cardiovascular outcomes in patients with stable coronary artery disease2020 · 45 citations
  2. 2Prognosis after switching to electronic cigarettes following percutaneous coronary intervention: a Korean nationwide study2024 · 28 citations
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  4. 4Medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial2022 · 37 citations
  5. 5AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2011 Update2011 · 1,770 citations