Key result
Patients with MINOCA had a significantly higher risk of all-cause death or recurrent non-fatal MI compared to a matched cohort without cardiovascular disease (HR 4.64; 95% CI 3.54-6.10; P<0.0001).
Why the study?
Does MINOCA or obstructive CAD increase the risk of all-cause death or recurrent non-fatal MI compared to a matched population without CVD?
Population
8,305 consecutive patients undergoing coronary angiography for MI and an age and sex-matched cohort without…
Comparison
Myocardial infarction with non-obstructive… vs Age and sex-matched cohort without known…
Design
Cohort
Follow-up
2 years
Authors
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MINOCA warrants closer surveillance than no-CVD controls; leaves open optimal secondary prevention pending randomized data.
Cohort (n=8,305)
Yes
Does MINOCA or obstructive CAD increase the risk of all-cause death or recurrent non-fatal MI compared to a matched population without CVD?
Hazard Ratio: 4.64 (95% CI 3.54–6.1)
p-value: p=<0.0001
MINOCA is associated with a significantly higher risk of death or recurrent MI compared to a population without CVD, though the risk is lower than in obstructive CAD, with non-CVD death being the predominant cause of mortality.
Williams et al. (2018) conducted a cohort in Myocardial infarction (n=8,305). MINOCA vs. Age and sex-matched cohort without cardiovascular disease was evaluated on All-cause death or recurrent non-fatal MI (HR 4.64, 95% CI 3.54 to 6.10, p=<0.0001). Patients with MINOCA had a significantly higher risk of all-cause death or recurrent non-fatal MI compared to a matched cohort without cardiovascular disease (HR 4.64; 95% CI 3.54-6.10; P<0.0001).