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July 9, 2019Journal of the American Heart AssociationOpen Access

Patients with MINOCA and MI with obstructive CAD showed similar incidence of 2-year all-cause death (9.1% versus 8.8%; HR 1.04, 95% CI 0.74-1.45, P=0.83).

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Why the study?

The prognosis and predictors of mortality in patients with MINOCA remain unclear.

Does MINOCA have a different prognosis compared to myocardial infarction with obstructive coronary artery disease?

Population

396 MINOCA and 10 871 MI with obstructive CAD patients undergoing coronary angiography

Comparison

MINOCA vs myocardial infarction with obstructive coronary artery disease

Design

Nation-wide multicenter prospective registry

Follow-up

2 years

Authors

ECEun Ho ChooKCKiyuk ChangKLKwan Yong Lee

Discussion

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Overview

MINOCA carries similar 2-year mortality risk as obstructive MI; leaves open whether targeted therapies improve outcomes in this observational cohort.

Structured PICO

Does MINOCA have a different prognosis compared to myocardial infarction with obstructive coronary artery disease?

P
Population
11,267 patients (396 MINOCA, 10,871 MI with obstructive CAD) without previous history of significant coronary artery disease who underwent coronary angiography, from a nation-wide, multicenter, prospective registry.
I
Intervention
Myocardial infarction with nonobstructive coronary arteries (MINOCA)
C
Comparator
Myocardial infarction with obstructive coronary artery disease
O
Outcome
2-year all-cause deathhard clinical

Patients with MINOCA have comparable 2-year all-cause mortality to those with obstructive CAD, and the use of RAS blockers and statins is associated with lower mortality in MINOCA.

Cite This Study

Choo et al. (2019) studied this question.

synapsesocial.com/papers/6a7d68df469c795fc427a136https://doi.org/10.1161/jaha.119.011990
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical characteristics and prognosis of myocardial infarction with non-obstructive coronary arteries: A prospective single-center study2020 · 28 citations
  2. 2Long-term outcome of patients with myocardial infraction with nonobstructive coronary arteries2021 · 1 citations
  3. 3Prevalence, Clinical Features, Treatment, and Outcomes in Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries2024 · 1 citations
  4. 4Outcome after myocardial infarction without obstructive coronary artery disease2018 · 70 citations
  5. 5Clinical Characteristics Predicting Worse Long-Term Outcomes in Patients with Myocardial Infarction and Non-Obstructive Coronary Arteries (MINOCA)2022 · 7 citations