Cardiac injury and mortality in patients with Coronavirus disease 2019 (COVID-19): insights from a mediation analysis

Figures

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  Fig. 1. Levels of admission and peak Hs-cTnI in our cohort of COVID-19 patients. Compared with survivors, non-survivors presented higher median levels of Hs-cTnI both on admission (64 vs 6 ng/L, p < 0.001) (a) and peak levels during the hospitalization (279 vs 16 ng/L, p < 0.001) (b)

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  Fig. 2. Effect of peak Hs-cTnI on mortality. Non-linear effect (p < 0.001) of Hs-cTnI from 0 to 200 ng/L is to increase risk of death by odds ratio (OR) 6.92 (95% CI 2.39–19.99). Curvature changes to a plateau at 209.18 ng/L (95% CI 110.80–365.75)

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  Fig. 3. Mediation analysis of an abnormal Hs-cTnI. Average causal mediation effect (ACME) and average direct effect (ADE). Effects are the increase (decrease) in probability of the outcome between risk factor’s levels