February 1, 1974Clinical and Experimental Pharmacology and Physiology

The Haemodynamic Effects of Quazodine, a Cardiac Stimulant, in Experimental E. Coli Endotoxin Shock in the Cat

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Why the study?

Does quazodine improve haemodynamic parameters in pentobarbitone-anaesthetized cats with experimental E. coli endotoxin shock?

Population

Pentobarbitone-anaesthetized cats with experimental E. coli endotoxin shock

Design

Preclinical

Follow-up

3 hours

Authors

JPJ. R. ParrattUniversity of London EWE. WinslowUniversité d'Orléans

Discussion

Member takes

Implication

Quazodine ineffective against myocardial depression in feline endotoxin shock; leaves open translation to other models or species.

Structured PICO

Does quazodine improve haemodynamic parameters in pentobarbitone-anaesthetized cats with experimental E. coli endotoxin shock?

Population

Pentobarbitone-anaesthetized cats with experimental E. coli endotoxin shock (induced by 2 mg/kg IV E. coli endotoxin)

Intervention

Intravenous injections of quazodine (6,7-dimethoxy-4-ethylquinazoline, 0-5 mg/kg per min)

Outcome

Haemodynamic effects including heart rate, maximum rate of pressure development in the left ventricle (LV dP/dt max.), cardiac output, myocardial blood flow, and systemic arterial blood pressuresurrogate

Quazodine is ineffective at reversing the profound myocardial depression associated with severe E. coli endotoxin shock in a feline model.

Cite This Study

Parratt et al. (1974) studied this question.

synapsesocial.com/papers/6a1017d4fa36b6e053fd3a72 https://doi.org/10.1111/j.1440-1681.1974.tb00524.x

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The Haemodynamic Effects of Quazodine, a Cardiac Stimulant, in Experimental E. Coli Endotoxin Shock in the Cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Haemodynamic Effects of Quazodine, a Cardiac Stimulant, in Experimental E. Coli Endotoxin Shock in the Cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider