November 14, 2010AtherosclerosisOpen Access

Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells

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Structured PICO

Population

Primary human aortic endothelial cells (HAEC) in vitro and mice in vivo

Intervention

Adenovirus-mediated overexpression of catalytically active endothelial lipase (EL) and administration of EL-generated lysophosphatidylcholines (LPC 16:0, 18:1, 20:4, 18:2)

Comparator

Adenovirus-mediated overexpression of inactive mutant EL, or control conditions

Outcome

Interleukin-8 (IL-8) mRNA and protein synthesis in HAEC, and MIP-2 (murine IL-8 analogue) plasma levels in micesurrogate

Endothelial lipase and specific EL-generated lysophosphatidylcholines promote the synthesis of the pro-inflammatory chemokine IL-8, suggesting a mechanistic role in atherosclerosis development.

Discussion

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Implication

Highlights potential mechanistic link between EL activity and vascular inflammation; leaves open clinical translation and therapeutic targeting in atherosclerosis.

Cite This Study

Riederer et al. (2010) studied this question.

synapsesocial.com/papers/6a1018758090e499da609c41 https://doi.org/10.1016/j.atherosclerosis.2010.11.007

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Implication

Highlights potential mechanistic link between EL activity and vascular inflammation; leaves open clinical translation and therapeutic targeting in atherosclerosis.

Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells

Structured PICO

Discussion

Implication

Cite This Study

Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider