Key result
Deep-etch replica electron microscopy revealed that individual connectin molecules stretch between the M and Z lines, forming elastic filaments laterally associated with myosin and actin.
Population
Cardiac muscle fibers
Comparison
Selective removal of actin and myosin filaments… vs Replica images of intact and S1-decorated…
Design
Preclinical
Authors
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Extends sarcomere elasticity models from animal data; leaves open relevance to human titinopathies or HF.
Deep-etch replica analysis reveals that connectin (titin) filaments stretch between the M and Z lines and laterally associate with actin and myosin in cardiac muscle sarcomeres.
Funatsu et al. (1993) studied Cardiac muscle structure. Selective removal of actin and myosin filaments vs. Intact and S1-decorated sarcomeres was evaluated on Observation of residual elastic filament network. Deep-etch replica electron microscopy revealed that individual connectin molecules stretch between the M and Z lines, forming elastic filaments laterally associated with myosin and actin.
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