Key result
Deep-etch replica electron microscopy revealed that individual connectin molecules stretch between the M and Z lines, forming elastic filaments laterally associated with myosin and actin.
Deep-etch replica analysis reveals that connectin (titin) filaments stretch between the M and Z lines and laterally associate with actin and myosin in cardiac muscle sarcomeres.
No takes yet. Share an insight, caveat, or question.
Extends sarcomere elasticity models from animal data; leaves open relevance to human titinopathies or HF.
Funatsu et al. (1993) studied Cardiac muscle structure. Selective removal of actin and myosin filaments vs. Intact and S1-decorated sarcomeres was evaluated on Observation of residual elastic filament network. Deep-etch replica electron microscopy revealed that individual connectin molecules stretch between the M and Z lines, forming elastic filaments laterally associated with myosin and actin.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: