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January 1, 1981The Journal of Biochemistry

Connectin, an Elastic Protein of Muscle. Identification of “Titin” with Connectin1

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Population

Rabbit and chicken skeletal muscles (whole muscle fibers or myofibrils)

Design

Preclinical

Authors

KMKosçak MaruyamaChiba UniversitySKSumiko KimuraJikei University School of MedicineKOKazuyo OhashiChiba University

Discussion

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Implication

Unifies nomenclature for the giant sarcomeric protein; leaves open its roles in human cardiomyopathy.

Structured PICO

P
Population
Rabbit and chicken skeletal muscles (whole muscle fibers or myofibrils)
I
Intervention
Protein isolation via hot SDS solution and gel filtration, followed by electrophoretic mobility, amino acid composition analysis, and indirect immunofluorescence
O
Outcome
Identification of titin and connectin as the same proteinsurrogate

This basic science study demonstrates that the elastic muscle proteins titin and connectin are identical.

Cite This Study

Maruyama et al. (1981) studied this question.

synapsesocial.com/papers/6a6f484fb27f15817826ed8bhttps://doi.org/10.1093/oxfordjournals.jbchem.a133249
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Connectin/titin, giant elastic protein of muscle1997 · 241 citations
  2. 2Connectin filaments in stretched skinned fibers of frog skeletal muscle.1984 · 73 citations
  3. 3Elastic behavior of connectin filaments during thick filament movement in activated skeletal muscle.1989 · 100 citations
  4. 4Sodium Dodecyl Sulfate Gel Electrophoresis Studies of Connectin-Like High Molecular Weight Proteins of Various Types of Vertebrate and Invertebrate Muscles11986 · 98 citations
  5. 5Connectin, an Elastic Protein of Muscle<subtitle>Its Abundance in Cardiac Myofibrils<xref ref-type="fn" rid="fn1"><sup>1</sup></xref></subtitle>1977 · 36 citations