Resuscitation After Prolonged Ventricular Fibrillation With Use of Monophasic and Biphasic Waveform Pulses for External Defibrillation
Key result
Biphasic waveform pulses for external defibrillation resulted in lower mean defibrillation thresholds (107 vs 172 J; P=0.04) and shorter resuscitation times compared to monophasic pulses in dogs.
Why the study?
Does external defibrillation with biphasic waveforms improve hemodynamics and reduce defibrillation thresholds compared to monophasic waveforms in a canine model of prolonged ventricular fibrillation?
Population
26 dogs in a model of prolonged ventricular fibrillation
Comparison
External countershocks with biphasic waveforms vs External countershocks with monophasic waveforms
Design
Preclinical, randomized
Authors
Discussion
Loading...
Member takes
Implication
May guide veterinary resuscitation; leaves open translation to human external defibrillation.
Study Design
Type
RCT (n=26)
Structured PICO
Does external defibrillation with biphasic waveforms improve hemodynamics and reduce defibrillation thresholds compared to monophasic waveforms in a canine model of prolonged ventricular fibrillation?
P
Population
26 dogs in a model of prolonged ventricular fibrillation
I
Intervention
External countershocks with biphasic (BP) waveforms
C
Comparator
External countershocks with monophasic (MP) waveforms
O
Outcome
Hemodynamics (percent change in left ventricular +dP/dt(max) and -dP/dt(max)), defibrillation thresholds, and resuscitation timessurrogate
Main Result
Absolute Event Rate: 107% vs 172%
p-value: p=0.04
Biphasic waveforms are more efficacious than monophasic waveforms for external defibrillation, resulting in lower defibrillation thresholds and shorter resuscitation times in a canine model of prolonged VF.
Cite This Study
Leng et al. (2000) conducted an RCT in Ventricular fibrillation (n=26). Biphasic waveform pulses vs. Monophasic waveform pulses was evaluated on Mean defibrillation threshold after prolonged ventricular fibrillation (p=0.04). Biphasic waveform pulses for external defibrillation resulted in lower mean defibrillation thresholds (107 vs 172 J; P=0.04) and shorter resuscitation times compared to monophasic pulses in dogs.