Cardiac responses to premature monophasic and biphasic field stimuli
Key result
Biphasic stimuli at low-field strengths elicit a graded excitatory response that prevents the formation of large spatial transmembrane voltage gradients and renewed propagated wave fronts.
Population
Two separate, but related, computer models of active cardiac cells and tissue
Comparison
Idealized premature extracellular biphasic field… vs Idealized premature extracellular monophasic…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for optimized defibrillation waveforms; animal data leave clinical translation of low-field biphasic stimuli untested.
Structured PICO
P
Population
Two separate, but related, computer models of active cardiac cells and tissue
I
Intervention
Idealized premature extracellular biphasic (BP) field stimuli
C
Comparator
Idealized premature extracellular monophasic (MP) field stimuli
O
Outcome
Excitation responses of active cardiac cells and tissue (including spatial transmembrane voltage profile and propagation wave fronts)surrogate
Computer modeling suggests biphasic defibrillation is superior to monophasic because it produces a graded excitatory response at low field strengths, preventing large transmembrane voltage gradients and renewed wave fronts.
Cite This Study
Fishler et al. (1995) studied Cardiac defibrillation. Biphasic field stimuli vs. Monophasic field stimuli was evaluated on Excitation responses of active cardiac cells and tissue. Biphasic stimuli at low-field strengths elicit a graded excitatory response that prevents the formation of large spatial transmembrane voltage gradients and renewed propagated wave fronts.