Key result
Balanced-charge biphasic waveforms prolong action potential duration versus monophasic waveforms in a computer model.
Why the study?
Does a balanced-charge biphasic waveform produce a longer mean total APD than a comparable monophasic waveform in a computer model of the ventricular action potential?
Population
Computer model of the ventricular action potential
Comparison
Balanced-charge symmetrical biphasic waveforms… vs Monophasic waveforms
Design
Preclinical
Authors
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May support biphasic waveform modeling for defibrillation; leaves open translation beyond computer simulations.
Does a balanced-charge biphasic waveform produce a longer mean total APD than a comparable monophasic waveform in a computer model of the ventricular action potential?
Biphasic waveforms enhance the prolonged refractory periods required for defibrillation throughout the heart, explaining their improved efficacy at low shock intensities.
Jones et al. (1995) studied Ventricular fibrillation. Balanced-charge symmetrical biphasic waveforms vs. Monophasic waveforms was evaluated on Transmembrane potential changes and action potential duration (APD90). Balanced-charge biphasic waveforms produced a significantly longer response under hyperpolarizing and depolarizing conditions than monophasic waveforms in a computer model.
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