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June 1, 1989Circulation ResearchOpen Access

Improved safety factor for triphasic defibrillator waveforms.

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Population

Cultured myocardial cells

Comparison

Triphasic waveform consisting of a biphasic… vs Control monophasic rectangular waveform and a…

Design

Preclinical

Authors

JJJanice L. JonesRJR. E. Jones

Discussion

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Overview

Triphasic waveforms may reduce postshock dysfunction versus biphasic in this cell model; hypothesis-generating and requires in vivo confirmation before clinical consideration.

Structured PICO

P
Population
Cultured myocardial cells
I
Intervention
Triphasic waveform consisting of a biphasic waveform with an added 10% 'tail' (each portion 5 msec in duration)
C
Comparator
Control monophasic rectangular waveform and a symmetrical biphasic waveform
O
Outcome
Voltage gradient producing a 4-second arrest of spontaneous contractile activitysurrogate

Triphasic defibrillator waveforms may offer a higher safety factor than biphasic waveforms by reducing postshock dysfunction in cultured myocardial cells.

Cite This Study

Jones et al. (1989) studied this question.

synapsesocial.com/papers/6a8a4ecf755d28965dfd646ahttps://doi.org/10.1161/01.res.64.6.1172
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved defibrillator waveform safety factor with biphasic waveforms1983 · 93 citations
  2. 2Improved cardiac cell excitation with symmetrical biphasic defibrillator waveforms1987 · 99 citations
  3. 3Decreased defibrillator-induced dysfunction with biphasic rectangular waveforms1984 · 104 citations
  4. 4Determination of safety factor for defibrillator waveforms in cultured heart cells1982 · 25 citations
  5. 5Defibrillation of 100 kg calves with asymmetrical, bidirectional, rectangular pulses1984 · 82 citations