What question did this study set out to answer?

To determine postshock dysfunction and safety factor strength-duration curves for symmetric and asymmetric monophasic and biphasic defibrillator waveforms.

January 1, 1994AJP Heart and Circulatory Physiology

Dysfunction and safety factor strength-duration curves for biphasic defibrillator waveforms

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Why the study?

Do asymmetric biphasic waveforms improve safety factor and reduce postshock dysfunction compared to monophasic waveforms in preclinical models?

Population

Preclinical model (unspecified in abstract) for testing defibrillator waveforms

Comparison

Symmetric and asymmetric biphasic rectangular… vs Monophasic control waveforms

Design

Preclinical

Authors

JJJanice L. JonesUniversity of North Carolina at Chapel Hill KMKevin MilneUnited States Department of Veterans Affairs

Discussion

Member takes

Overview

May enhance defibrillation safety in models; leaves open clinical translation and practice change.

Key Points

To determine postshock dysfunction and safety factor strength-duration curves for symmetric and asymmetric monophasic and biphasic defibrillator waveforms.
Evaluated rectangular (0%-tilt) symmetric and asymmetric (50% undershoot) monophasic and biphasic waveforms across total durations ranging from 1 to 40 ms.
Measured dysfunction threshold, defined as the voltage required to induce a 4-second postshock contractile arrest.
Dysfunction thresholds decreased with increasing waveform duration across all tested configurations from 1 to 40 ms.
Symmetric monophasic and biphasic waveforms of identical total duration produced similar dysfunction thresholds across all durations.
Asymmetric biphasic waveforms increased the dysfunction threshold by 14 ± 3% compared with monophasic controls (P < 0.005).

Structured PICO

Do asymmetric biphasic waveforms improve safety factor and reduce postshock dysfunction compared to monophasic waveforms in preclinical models?

Population

Preclinical model (unspecified in abstract) for testing defibrillator waveforms

Intervention

Symmetric and asymmetric (50% undershoot) biphasic rectangular (0%-tilt) waveforms with total durations from 1 to 40 ms

Comparator

Monophasic control waveforms

Outcome

Dysfunction threshold (voltage producing a 4-s postshock contractile arrest) and safety factorsurrogate

Asymmetric biphasic waveforms improve the safety factor of defibrillation by reducing postshock dysfunction compared to monophasic waveforms.

Cite This Study

Jones et al. (1994) studied this question.

synapsesocial.com/papers/6a868cba1d4e7816c90cf8d5 https://doi.org/10.1152/ajpheart.1994.266.1.h263

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January 1, 1994AJP Heart and Circulatory Physiology

Dysfunction and safety factor strength-duration curves for biphasic defibrillator waveforms

View Full Paper

Ask AI

Bookmark

Why the study?

Do asymmetric biphasic waveforms improve safety factor and reduce postshock dysfunction compared to monophasic waveforms in preclinical models?

Population

Preclinical model (unspecified in abstract) for testing defibrillator waveforms

Comparison

Symmetric and asymmetric biphasic rectangular… vs Monophasic control waveforms

Design

Preclinical

Authors

JJJanice L. JonesUniversity of North Carolina at Chapel Hill KMKevin MilneUnited States Department of Veterans Affairs

Discussion

Member takes

Overview

May enhance defibrillation safety in models; leaves open clinical translation and practice change.

Key Points

To determine postshock dysfunction and safety factor strength-duration curves for symmetric and asymmetric monophasic and biphasic defibrillator waveforms.
Evaluated rectangular (0%-tilt) symmetric and asymmetric (50% undershoot) monophasic and biphasic waveforms across total durations ranging from 1 to 40 ms.
Measured dysfunction threshold, defined as the voltage required to induce a 4-second postshock contractile arrest.
Dysfunction thresholds decreased with increasing waveform duration across all tested configurations from 1 to 40 ms.
Symmetric monophasic and biphasic waveforms of identical total duration produced similar dysfunction thresholds across all durations.
Asymmetric biphasic waveforms increased the dysfunction threshold by 14 ± 3% compared with monophasic controls (P < 0.005).

Structured PICO

Do asymmetric biphasic waveforms improve safety factor and reduce postshock dysfunction compared to monophasic waveforms in preclinical models?

Population

Preclinical model (unspecified in abstract) for testing defibrillator waveforms

Intervention

Symmetric and asymmetric (50% undershoot) biphasic rectangular (0%-tilt) waveforms with total durations from 1 to 40 ms

Comparator

Monophasic control waveforms

Outcome

Dysfunction threshold (voltage producing a 4-s postshock contractile arrest) and safety factorsurrogate

Asymmetric biphasic waveforms improve the safety factor of defibrillation by reducing postshock dysfunction compared to monophasic waveforms.

Cite This Study

Jones et al. (1994) studied this question.

synapsesocial.com/papers/6a868cba1d4e7816c90cf8d5 https://doi.org/10.1152/ajpheart.1994.266.1.h263

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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