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August 1, 1990Circulation ResearchOpen Access

Increasing fibrillation duration enhances relative asymmetrical biphasic versus monophasic defibrillator waveform efficacy.

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Why the study?

Does an asymmetrical biphasic waveform reduce defibrillation threshold compared to a monophasic waveform in isolated rabbit hearts at varying fibrillation durations?

Population

Isolated right- and left-sided working rabbit hearts (n=10)

Comparison

Asymmetrical biphasic waveform vs Monophasic waveform (5 msec rectangular)

Design

Preclinical

Authors

JJJanice L. JonesUniversity of North Carolina at Chapel HillJSJohn SwartzKansas City UniversityRJR. E. JonesUniversity Hospitals Bristol NHS Foundation Trust

Discussion

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Implication

Animal findings extend biphasic advantage to longer fibrillation; leaves open human translation.

Structured PICO

Does an asymmetrical biphasic waveform reduce defibrillation threshold compared to a monophasic waveform in isolated rabbit hearts at varying fibrillation durations?

P
Population
Isolated right- and left-sided working rabbit hearts (n=10)
I
Intervention
Asymmetrical biphasic waveform (5 msec each pulse, V2 = 50% V1)
C
Comparator
Monophasic waveform (5 msec rectangular)
O
Outcome
Mean voltage defibrillation threshold (V50) and energy threshold after 5, 15, and 30 seconds of fibrillationsurrogate

Biphasic defibrillation waveforms demonstrate lower voltage and energy thresholds than monophasic waveforms in a rabbit model, with the relative advantage increasing as fibrillation duration lengthens.

Cite This Study

Jones et al. (1990) studied this question.

synapsesocial.com/papers/6a868cba1d4e7816c90cf8dahttps://doi.org/10.1161/01.res.67.2.376
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased defibrillator-induced dysfunction with biphasic rectangular waveforms1984 · 104 citations
  2. 2Defibrillation of 100 kg calves with asymmetrical, bidirectional, rectangular pulses1984 · 82 citations
  3. 3Effects of Time to Defibrillation and Subthreshold Preshocks on Defibrillation Success in Pigs1989 · 28 citations
  4. 4Intracellular recording of in situ ventricular cells during ventricular fibrillation1981 · 79 citations
  5. 5Clinical experience, complications, and survival in 70 patients with the automatic implantable cardioverter/defibrillator.1985 · 452 citations