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July 1, 1983AJP Heart and Circulatory Physiology

Improved defibrillator waveform safety factor with biphasic waveforms

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Why the study?

Do biphasic waveforms improve the safety factor compared to truncated or rectified waveforms in cultured myocardial cells?

Population

Cultured "adult-type" chick embryo myocardial cells

Comparison

Electric field stimulation with biphasic waveforms vs Electric field stimulation with truncated and…

Design

Preclinical

Authors

JJJanice L. JonesRJR. E. Jones

Discussion

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Overview

Biphasic waveforms may confer safety advantages in vitro; leaves open clinical translation pending human defibrillation trials.

Structured PICO

Do biphasic waveforms improve the safety factor compared to truncated or rectified waveforms in cultured myocardial cells?

P
Population
Cultured "adult-type" chick embryo myocardial cells
I
Intervention
Electric field stimulation with biphasic waveforms
C
Comparator
Electric field stimulation with truncated and rectified underdamped RLC (resistance-inductance-capacitance) type waveforms
O
Outcome
Safety factor (ratio between shock intensity producing specific dysfunction and that producing excitation)surrogate

Biphasic waveforms demonstrate a higher safety factor in cultured myocardial cells, suggesting they may improve the efficacy and safety of clinical cardiac defibrillation.

Cite This Study

Jones et al. (1983) studied this question.

synapsesocial.com/papers/6a868cba1d4e7816c90cf8ddhttps://doi.org/10.1152/ajpheart.1983.245.1.h60
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved safety factor for triphasic defibrillator waveforms.1989 · 21 citations
  2. 2Dysfunction and safety factor strength-duration curves for biphasic defibrillator waveforms1994 · 23 citations
  3. 3Determination of safety factor for defibrillator waveforms in cultured heart cells1982 · 25 citations
  4. 4Decreased defibrillator-induced dysfunction with biphasic rectangular waveforms1984 · 104 citations
  5. 5Improved cardiac cell excitation with symmetrical biphasic defibrillator waveforms1987 · 99 citations