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April 1, 1982AJP Heart and Circulatory Physiology

Determination of safety factor for defibrillator waveforms in cultured heart cells

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Why the study?

Does the safety factor of defibrillator waveforms in cultured heart cells correlate with in situ defibrillating effectiveness?

Population

Cultured chick embryo myocardial cells

Comparison

Electric shocks using rectangular, untruncated… vs Comparison between different waveforms

Design

Preclinical

Authors

JJJanice L. JonesRJR. E. Jones

Discussion

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Overview

Supports in vitro waveform screening in cell models; leaves open clinical translation and device optimization.

Structured PICO

Does the safety factor of defibrillator waveforms in cultured heart cells correlate with in situ defibrillating effectiveness?

P
Population
Cultured chick embryo myocardial cells
I
Intervention
Electric shocks using rectangular, untruncated resistor-capacitor (RC), and critically damped resistor-inductor-capacitor (RLC) waveforms with variable intensities
C
Comparator
Comparison between different waveforms (e.g., monophasic clinical waveforms vs. 5-ms rectangular wave)
O
Outcome
Excitation thresholds and production of a specific postshock arrhythmia (4-s arrest) to determine the safety factorsurrogate

In vitro safety factors of defibrillator waveforms in cultured heart cells closely correspond to in situ effectiveness, suggesting cell culture is a viable screening system for improving defibrillation safety and efficacy.

Cite This Study

Jones et al. (1982) studied this question.

synapsesocial.com/papers/6a736a02dea3f1d1ad56645fhttps://doi.org/10.1152/ajpheart.1982.242.4.h662
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