Population
Langendorff-perfused rabbit heart model (n=17 hearts, yielding 45,288 optical records)
Comparison
Mono- and biphasic defibrillation shocks applied… vs Internal comparisons across different shock…
Design
Preclinical
Authors
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Membrane tau >1 ms in this model suggests slower defibrillation edges may limit damage; hypothesis-generating in animals, human validation required.
The myocardial membrane time constant during defibrillation exceeds 1 msec, suggesting that slower shock leading edges should be used to avoid membrane damage.
Kent A. Mowrey (2002) studied this question.
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