Why the study?
Do symmetrical biphasic rectangular waveforms reduce excitation threshold in cultured cardiac cells compared to monophasic waveforms?
Population
100- to 250-microns aggregates from 10- to 12-day-old chick embryos (cultured cell model)
Comparison
Symmetrical biphasic rectangular waveforms vs Corresponding monophasic waveforms
Design
Preclinical
Authors
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May inform waveform selection in defibrillators; leaves open translation from cell models to clinical efficacy.
Do symmetrical biphasic rectangular waveforms reduce excitation threshold in cultured cardiac cells compared to monophasic waveforms?
Symmetrical biphasic waveforms significantly decrease the excitation threshold in cultured cardiac cells compared to monophasic waveforms, supporting their improved efficacy for defibrillation.
Jones et al. (1987) studied this question.
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