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November 1, 1984AJP Heart and Circulatory Physiology

Decreased defibrillator-induced dysfunction with biphasic rectangular waveforms

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Population

Cultured myocardial cells

Comparison

Biphasic rectangular waveforms with negative… vs Monophasic 5-ms rectangular waveforms of about…

Design

Preclinical

Authors

JJJanice L. JonesRJR. E. Jones

Discussion

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Overview

Hypothesis-generating for undershoot-optimized biphasic waveforms; prospective clinical trials required before any practice implications.

Structured PICO

P
Population
Cultured myocardial cells
I
Intervention
Biphasic rectangular waveforms with negative "tails" 1-100 ms in duration and 5-100% of the initial positive portion in amplitude
C
Comparator
Monophasic 5-ms rectangular waveforms of about 80 V/cm
O
Outcome
Postshock arrest time of contractile activitysurrogate

Biphasic defibrillation waveforms with low amplitude tails ameliorate postshock myocardial dysfunction in cultured cells, supporting the hypothesis of electromechanical breakdown of the cell membrane.

Cite This Study

Jones et al. (1984) studied this question.

synapsesocial.com/papers/6a868cba1d4e7816c90cf8dchttps://doi.org/10.1152/ajpheart.1984.247.5.h792
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved defibrillator waveform safety factor with biphasic waveforms1983 · 93 citations
  2. 2Threshold reduction with biphasic defibrillator waveforms1995 · 25 citations
  3. 3Improved safety factor for triphasic defibrillator waveforms.1989 · 21 citations
  4. 4Postshock Potential Gradients and Dispersion of Repolarization in Cells Stimulated with Monophasic and Biphasic Waveforms1998 · 6 citations
  5. 5Individual effect of components of defibrillation waveform on the contractile function and intracellular calcium dynamics of cardiomyocytes*2009 · 11 citations