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January 1, 1994IEEE Transactions on Biomedical Engineering

Refractory period prolongation by biphasic defibrillator waveforms is associated with enhanced sodium current in a computer model of the ventricular action potential

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Why the study?

Does biphasic waveform stimulation enhance sodium current and prolong refractory period responses compared to monophasic shocks in a ventricular action potential model?

Population

Beeler-Reuter ventricular action potential computer model with the Drouhard-Roberge (BRDR) modification

Comparison

Symmetrical biphasic shocks delivered during the… vs Monophasic shocks (MS2, 10 msec)

Design

Preclinical

Authors

JJJanice L. JonesUniversity of North Carolina at Chapel HillRJR. E. JonesUniversity Hospitals Bristol NHS Foundation TrustKMKevin MilneUnited States Department of Veterans Affairs

Discussion

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Implication

May underlie biphasic defibrillation efficacy in models; hypothesis-generating and leaves open in vivo confirmation.

Structured PICO

Does biphasic waveform stimulation enhance sodium current and prolong refractory period responses compared to monophasic shocks in a ventricular action potential model?

P
Population
Beeler-Reuter ventricular action potential computer model with the Drouhard-Roberge (BRDR) modification
I
Intervention
Symmetrical biphasic shocks (BS2, 10 msec each pulse) delivered during the refractory period
C
Comparator
Monophasic shocks (MS2, 10 msec)
O
Outcome
Action potential response duration and sodium currentsurrogate

In a computer model, biphasic waveforms enhance sodium current and prolong refractory period responses compared to monophasic shocks, potentially explaining their enhanced defibrillating efficacy.

Cite This Study

Jones et al. (1994) studied this question.

synapsesocial.com/papers/6a75fca774b63c188eb20c80https://doi.org/10.1109/10.277272
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conditioning prepulse of biphasic defibrillator waveforms enhances refractoriness to fibrillation wavefronts.1991 · 80 citations
  2. 2Threshold reduction with biphasic defibrillator waveforms1995 · 25 citations
  3. 3Prolongation of repolarization time by electric field stimulation with monophasic and biphasic shocks in open-chest dogs.1991 · 86 citations
  4. 4Postshock Potential Gradients and Dispersion of Repolarization in Cells Stimulated with Monophasic and Biphasic Waveforms1998 · 6 citations
  5. 5Membrane Refractoriness and Excitation Induced in Cardiac Fibers by Monophasic and Biphasic Shocks1997 · 17 citations