December 1, 1996Journal of Cardiovascular Electrophysiology
Modeling the Interaction Between Propagating Cardiac Waves and Monophasic and Biphasic Field Stimuli:
Why the study?
Does biphasic field stimulation prevent the initiation of new postshock activation fronts compared to monophasic stimulation in a computer model of a cardiac strand?
Population
Idealized computer model of a one-dimensional cardiac strand
Comparison
Biphasic (BP) field stimuli of various intensities vs Monophasic field stimuli of various intensities
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May reduce postshock wavefront reinitiation via graded biphasic responses; leaves open clinical translation from this animal model.
Structured PICO
Does biphasic field stimulation prevent the initiation of new postshock activation fronts compared to monophasic stimulation in a computer model of a cardiac strand?
P
Population
Idealized computer model of a one-dimensional cardiac strand
I
Intervention
Biphasic (BP) field stimuli of various intensities
C
Comparator
Monophasic (MP) field stimuli of various intensities
O
Outcome
Spatial and temporal interactions between an underlying propagation front (or tail) and uniform MP or BP field stimuli, specifically the initiation of new postshock activation frontssurrogate
Biphasic defibrillation waveforms may be more efficacious than monophasic waveforms because they induce graded excitatory responses at lower stimulus strengths, preventing the initiation of new propagating wavefronts in low gradient regions.
Cite This Study
Fishler et al. (1996) studied this question.