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September 4, 2006European Heart JournalOpen Access

The diagnostic utility of N-terminal pro-B-type natriuretic peptide for the detection of major structural heart disease in patients with atrial fibrillation

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Why the study?

Does NT-proBNP measurement accurately detect major structural heart disease in patients with atrial fibrillation compared to those with sinus rhythm?

Population

1,321 patients undergoing assessment at a single centre

Comparison

NT-proBNP measurement vs Patients with sinus rhythm vs patients with…

Design

Cross-sectional, Assessment performed without the knowledge of NT-proBNP levels

Authors

RSRhidian J. SheltonCumberland Infirmary

Discussion

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Implication

Similar NT-proBNP performance for MSHD in AF and SR supports broader application; leaves open AF-specific threshold validation.

Structured PICO

Does NT-proBNP measurement accurately detect major structural heart disease in patients with atrial fibrillation compared to those with sinus rhythm?

P
Population
1,321 patients undergoing assessment at a single centre (excluding those with renal impairment, atrial flutter, or a pacemaker)
I
Intervention
NT-proBNP measurement
C
Comparator
Patients with sinus rhythm vs patients with atrial fibrillation
O
Outcome
Detection of major structural heart disease (MSHD) using receiver operator characteristic (ROC) analysissurrogate

NT-proBNP is equally effective at detecting major structural heart disease in patients with atrial fibrillation as in those with sinus rhythm, but requires significantly higher diagnostic cut-off levels.

Cite This Study

Rhidian J. Shelton (2006) studied this question.

synapsesocial.com/papers/6a101e214fb650da4ffef87fhttps://doi.org/10.1093/eurheartj/ehl233

Topics

Heart failureHFrEF treatmentAtrial fibrillationPersistent AF managementEchocardiography
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