What question did this study set out to answer?

To review the bidirectional endocrine and metabolic communication between the heart and adipose tissue, focusing on the roles of cardiokines and adipokines in cardiovascular health.

January 1, 2020Korean Circulation JournalOpen Access

Metabolic Crosstalk between the Heart and Fat

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Why the study?

Bi-directional crosstalk between adipose tissue and the myocardium is crucial to maintaining normal function, but the primary cardiokines and adipokines involved and the implications of their dysregulation require synthesis.

Design

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Authors

KFKimberly FerreroJohns Hopkins University WKWalter KochDuke University

Discussion

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Implication

May guide cardiometabolic research priorities; leaves open clinical translation of cardiokine/adipokine modulation.

Key Points

To review the bidirectional endocrine and metabolic communication between the heart and adipose tissue, focusing on the roles of cardiokines and adipokines in cardiovascular health.
Synthesized current literature examining the endocrine functions of the myocardium and its communication with distant visceral fat depots.
Evaluated the molecular mechanisms through which cardiac and adipose-derived secretomes modulate peripheral metabolic activity.
The heart functions as a true endocrine organ by secreting cardiokines that directly alter adipose tissue metabolism and peripheral substrate release.
Visceral adipose tissue participates in reciprocal signaling by releasing adipokines and metabolic substrates that sustain normal myocardial function.
Disruption of bidirectional heart-fat molecular crosstalk alters metabolic balance and promotes cardiovascular disease progression.

Cite This Study

Ferrero et al. (2020) studied this question.

synapsesocial.com/papers/6a10245201be78fe8160793e https://doi.org/10.4070/kcj.2019.0400

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Metabolic Crosstalk between the Heart and Fat

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolic Crosstalk between the Heart and Fat

Discussion

Member takes

Implication

Key Points

Cite This Study

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