What question did this study set out to answer?

To develop arrhythmia-insensitive inversion recovery MRI sequences to improve late gadolinium enhancement scar visualization and diffuse fibrosis quantification during heart rate variability.

May 6, 2013Magnetic Resonance in MedicineOpen Access

Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability

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Why the study?

Does a novel saturation pulse prepared heart-rate-independent inversion recovery sequence improve LGE imaging and T1 mapping compared to conventional sequences in the presence of arrhythmia?

Population

Numerical simulations, phantom, healthy subjects, and patients with suspected or known cardiovascular disease

Comparison

Saturation pulse prepared heart-rate-independent… vs Conventional LGE and modified Look-Locker…

Design

Other

Authors

SWSebastian WeingärtnerCardiac Imaging MAMehmet AkçakayaUniversity of Minnesota TBTamer BashaCairo University

Discussion

Member takes

Implication

May support arrhythmia-tolerant CMR; leaves open prospective validation before routine use.

Key Points

To develop arrhythmia-insensitive inversion recovery MRI sequences to improve late gadolinium enhancement scar visualization and diffuse fibrosis quantification during heart rate variability.
Engineered a saturation pulse prepared heart-rate-independent inversion recovery pre-pulse that combines saturation and inversion pulses to eliminate magnetization history across consecutive heartbeats.
Evaluated the novel sequence against conventional late gadolinium enhancement (LGE) and modified Look-Locker inversion sequences using numerical simulations, phantoms, healthy subjects, and patients with cardiovascular disease.
Simulations and phantom experiments demonstrated that the novel pre-pulse eliminated ghosting artifacts and produced nulling of healthy myocardium under arrhythmic conditions.
T1 mapping acquisition duration was reduced from 17 to 9 heartbeats while establishing insensitivity to heart rate at long T1 and increasing signal homogeneity at short T1.
In vivo testing in patients with atrial fibrillation confirmed improved myocardial nulling during LGE and enhanced signal homogeneity across the myocardium and blood pools.

Structured PICO

Does a novel saturation pulse prepared heart-rate-independent inversion recovery sequence improve LGE imaging and T1 mapping compared to conventional sequences in the presence of arrhythmia?

Population

Numerical simulations, phantom, healthy subjects, and patients with suspected or known cardiovascular disease (including a patient in atrial fibrillation)

Intervention

Saturation pulse prepared heart-rate-independent inversion recovery sequence for late gadolinium enhancement (LGE) imaging and T1 mapping

Comparator

Conventional LGE and modified Look-Locker inversion sequences

Outcome

Improved visualization of myocardial scar (reduced ghosting artifacts, perfect nulling) and quantification of diffuse fibrosis (reduced scan time, insensitivity to heart rate, increased signal homogeneity)surrogate

A novel saturation pulse prepared heart-rate-independent inversion recovery sequence improves LGE imaging and T1 mapping in patients with arrhythmias by reducing artifacts and scan time.

Cite This Study

Weingärtner et al. (2013) studied this question.

synapsesocial.com/papers/6a102e6692676d5461fdad2e https://doi.org/10.1002/mrm.24761

Topics

Atrial fibrillation Persistent AF management Cardiac MRI

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Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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