Why the study?
Evaluating diastolic dysfunction by CMR often requires specialized sequences that prolong test time or expensive feature-tracking software lacking clinical validation.
Does assessment of left ventricular longitudinal displacement by cine-CMR detect diastolic dysfunction in patients with aortic valve disease compared to normal controls?
Does assessment of left ventricular longitudinal displacement by cine-CMR detect diastolic dysfunction in patients with aortic valve disease compared to normal controls?
A simple linear measurement of LV longitudinal displacement by cine-CMR can detect significant differences in diastolic function between AVD patients and controls without requiring expensive software or prolonged exam time.
Answers are grounded in this paper and cite their sources.
Cine-CMR longitudinal displacement detects diastolic differences in AVD; hypothesis-generating and should not yet change practice.
BACKGROUND: Diastolic dysfunction, commonly evaluated by echocardiography, is an important early finding in many cardiomyopathies. Cardiac magnetic resonance (CMR) often requires specialized sequences that extends the test time. Recently, feature-tracking imaging has been made available, but still requires expensive software and lacks clinical validation. OBJECTIVE: To assess diastolic function in patients with aortic valve disease (AVD) and compare it with normal controls by evaluating left ventricular (LV) longitudinal displacement by CMR. METHODS: We compared 26 AVD patients with 19 normal controls. Diastolic function was evaluated as LV longitudinal displacement in 4-chamber view cine-CMR images using steady state free precession (SSFP) sequence during the entire cardiac cycle with temporal resolution < 50 ms. The resulting plot of atrioventricular junction (AVJ) position versus time generated variables of AVJ motion. Significance level of p < 0.05 was used. RESULTS: Maximum longitudinal displacement (0.12 vs. 0.17 cm), maximum velocity during early diastole (MVED, 0.6 vs. 1.4s-1), slope of the best-fit line of displacement in diastasis (VDS, 0.22 vs. 0.03s-1), and VDS/MVED ratio (0.35 vs. 0.02) were significantly reduced in AVD patients compared with controls, respectively. Aortic regurgitation showed significantly worse longitudinal LV shortening compared with aortic stenosis. Higher LV mass indicated worse diastolic dysfunction. CONCLUSIONS: A simple linear measurement detected significant differences on LV diastolic function between AVD patients and controls. LV mass was the only independent predictor of diastolic dysfunction in these patients. This method can help in the evaluation of diastolic dysfunction, improving cardiomyopathy detection by CMR, without prolonging exam time or depending on expensive software.
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Ribeiro et al. (2019) studied this question.
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