Key result
Obesity is linked to ~63% lower odds of high arterial stiffness in healthy elderly subjects.
Why the study?
An inverse correlation between obesity and arterial stiffness had been reported, but results in elderly subjects remained inconsistent.
Is body mass index inversely correlated with arterial stiffness measured by the cardio-ankle vascular index in healthy elderly subjects?
Cross-Sectional (n=629)
No
Is body mass index inversely correlated with arterial stiffness measured by the cardio-ankle vascular index in healthy elderly subjects?
Effect estimate: OR 0.371 (95% CI 0.228-0.604)
p-value: p=<0.001
In healthy elderly subjects, BMI is inversely correlated with arterial stiffness as measured by CAVI, suggesting obesity is a negative predictor of CAVI in this population.
Obesity-CAVI inverse link in healthy elderly is hypothesis-generating; leaves open causality, confounding, and need for longitudinal confirmation before any clinical inference.
An inverse correlation between obesity and arterial stiffness has been reported, but there are no consistent results in elderly subjects. This study examined the relationship between the arterial stiffness measured by the CAVI (cardio-ankle vascular index) and BMI (body mass index) in healthy elderly people. This study included 629 healthy elderly people aged 65 and over who underwent health examinations at a general hospital in Gyeonggi from July 2018 to June 2019. Metabolic syndrome was diagnosed using the criteria of the Adult Treatment Panel (ATP) III of the US National Cholesterol Education Program (NCEP). Among the criteria of NCEP-ATP III, the waist circumference and obesity criteria were based on the WHO criteria. All subjects underwent a biochemical blood test and an assessment of the CAVI. In both men and women, the CAVI was lower in the obese group than in the normal weight group. Gender (P=0.047), age (P0.001), BMI (P0.001), and waist circumference (P=0.008) were factors affecting the CAVI. Gender, high blood pressure, and hyperglycemia were independent positive predictors of the CAVI levels, while obesity was a negative predictor. Therefore, the CAVI and BMI showed an inverse correlation. In conclusion, there was an inverse correlation between the CAVI and BMI in the elderly, and obesity was a negative predictor of the CAVI.
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Kyung‐A Shin (2019) conducted a cross-sectional in Healthy elderly subjects (n=629). Obesity (BMI ≥25 kg/m2) vs. Normal weight (BMI 18.5-22.9 kg/m2) was evaluated on High cardio-ankle vascular index (CAVI ≥9 m/s) (OR 0.371, 95% CI 0.228-0.604, p=<0.001). In healthy elderly subjects, obesity was inversely correlated with arterial stiffness and served as a negative predictor for a high cardio-ankle vascular index (OR 0.371).
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