January 1, 1990Circulation ResearchOpen Access

Morphological development of the rat heart growing in oculo in the absence of hemodynamic work load.

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Why the study?

Does the absence of hemodynamic work load affect cardiac muscle development in fetal rat ventricles?

Structured PICO

Does the absence of hemodynamic work load affect cardiac muscle development in fetal rat ventricles?

Population

12-day fetal rat ventricle transplanted into the anterior eye chamber of adult host rats, along with 12-day fetal tissue and 3-, 8-, and 28-day-old normally growing rats for comparison

Intervention

Transplantation into the anterior eye chamber (in oculo) to remove hemodynamic work load

Comparator

Normally growing rats (in situ growing hearts)

Outcome

Morphological development of cardiac muscle (ultrastructure, myofibril development, mitoses, morphometric evaluation)surrogate

Fetal rat ventricular myocytes can proliferate and differentiate without hemodynamic load, though myofibril alignment remains incomplete.

Authors

SBSanford P. BishopRutgers, The State University of New Jersey PAPeter G. AndersonUniversity of Alabama at Birmingham DTDaniel TuckerFlorida State University

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications; leaves open whether hemodynamic load is required for full myofibril alignment in vivo.

Cite This Study

Bishop et al. (1990) studied this question.

synapsesocial.com/papers/6a1037abd8c5cf602efde197 https://doi.org/10.1161/01.res.66.1.84

View Full Paper

Ask AI

Bookmark

Morphological development of the rat heart growing in oculo in the absence of hemodynamic work load.

Structured PICO

Discussion

Implication

Cite This Study

Morphological development of the rat heart growing in oculo in the absence of hemodynamic work load.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider