Key result
Olmesartan and enalapril were equally effective in preventing cardiac and renal damage in spontaneously hypertensive rats, while olmesartan was more effective on vascular extracellular matrix.
Why the study?
Does olmesartan or enalapril improve cardiac, renal, and vascular extracellular matrix in spontaneously hypertensive rats?
Population
48 rats, treated from age 4 to 12 weeks.
Comparison
Olmesartan or enalapril administered from age 4… vs Untreated SHR and untreated WKY controls.
Design
Preclinical
Follow-up
8 weeks (from age 4 to 12 weeks)
Authors
Loading...
Preclinical rat data should not guide ARB or ACEI choice; leaves open differential vascular effects for human investigation.
Does olmesartan or enalapril improve cardiac, renal, and vascular extracellular matrix in spontaneously hypertensive rats?
In spontaneously hypertensive rats, olmesartan and enalapril equally prevent cardiac and renal damage, but olmesartan is more effective at improving vascular extracellular matrix.
Porteri et al. (2005) studied Hypertension (Spontaneously hypertensive rats) (n=48). Olmesartan and Enalapril vs. Untreated controls was evaluated on Cardiac, aortic and glomerular interstitial collagen content and media:lumen ratio. Olmesartan and enalapril were equally effective in preventing cardiac and renal damage in spontaneously hypertensive rats, while olmesartan was more effective on vascular extracellular matrix.