What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Suspected native coronary artery disease (n=40). Intervention: Central aortic pressure waveform characteristics (aorto-radial pulse wave velocity and augmentation index). Primary outcome: Association of aorto-radial pulse wave velocity and central aortic augmentation index with coronary artery disease extent and severity scores (p=<0.001).

October 1, 2007Journal of Hypertension

Arterial pulse wave velocity but not augmentation index is associated with coronary artery disease extent and severity: implications for arterial transfer function applicability

Q: What are the key findings of this study?

Aorto-radial pulse wave velocity, but not central aortic augmentation index, was independently associated with both the extent and severity of coronary artery disease (P < 0.001).

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Key result

Aorto-radial pulse wave velocity, but not central aortic augmentation index, was independently associated with both the extent and severity of coronary artery disease (P < 0.001).

Why the study?

Are central aortic pressure waveform characteristics (pulse wave velocity and augmentation index) associated with the extent and severity of coronary artery disease?

Population

40 patients (24 male) undergoing coronary angiography for suspected native coronary artery disease

Design

Cross-sectional, Disease severity and extent assessed independently by two…

Authors

SHSarah A. HopeRoyal Children's Hospital PAP. AntonisMonash Medical Centre DADavid AdamUL (Germany)

Discussion

Member takes

Implication

PWV may support CAD evaluation in select patients; leaves open incremental value over standard risk factors.

Study Design

Type

Cross-Sectional (n=40)

Structured PICO

Are central aortic pressure waveform characteristics (pulse wave velocity and augmentation index) associated with the extent and severity of coronary artery disease?

Population

40 patients (24 male) undergoing coronary angiography for suspected native coronary artery disease

Intervention

Measurement of aorto-radial pulse wave velocity and central aortic augmentation index using central aortic waveforms (2F Millar pressure transducer-tipped catheters)

Outcome

Severity and extent of coronary artery disease assessed by modified Gensini's stenosis and Sullivan's extent scoressurrogate

Main Result

p-value: p=<0.001

Cite This Study

Hope et al. (2007) conducted a cross-sectional in Suspected native coronary artery disease (n=40). Central aortic pressure waveform characteristics (aorto-radial pulse wave velocity and augmentation index) was evaluated on Association of aorto-radial pulse wave velocity and central aortic augmentation index with coronary artery disease extent and severity scores (p=<0.001). Aorto-radial pulse wave velocity, but not central aortic augmentation index, was independently associated with both the extent and severity of coronary artery disease (P < 0.001).

synapsesocial.com/papers/6a10446ad13714ec96ff7e69 https://doi.org/10.1097/hjh.0b013e3282a9be41

Topics

Coronary artery disease

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Arterial pulse wave velocity but not augmentation index is associated with coronary artery disease extent and severity: implications for arterial transfer function applicability

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Arterial pulse wave velocity but not augmentation index is associated with coronary artery disease extent and severity: implications for arterial transfer function applicability

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider