Pressure Wave Reflection Assessed From the Peripheral Pulse
Key result
Direct measurement of the radial augmentation index without a transfer function closely correlated with the aortic augmentation index (R=0.96), questioning the need for transfer functions.
Why the study?
Does radial augmentation index obtained without a transfer function accurately reflect central pressure wave reflection compared to indices derived using transfer functions?
Population
84 subjects including healthy volunteers, subjects with essential hypertension, and patients with coronary…
Comparison
Arterial tonometry to assess pressure wave… vs Aortic systolic blood pressure and aortic…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May support direct radial AIx measurement; challenges transfer function consensus yet leaves open prospective validation.
Study Design
Type
Observational (n=84)
Structured PICO
Does radial augmentation index obtained without a transfer function accurately reflect central pressure wave reflection compared to indices derived using transfer functions?
P
Population
84 subjects including healthy volunteers (n=30), subjects with essential hypertension (n=30), and patients with coronary artery disease (n=24).
I
Intervention
Arterial tonometry (Sphygmocor) to assess pressure wave reflection from the radial pulse without the use of a transfer function. A subset of 12 healthy volunteers received nitroglycerine and norepinephrine.
C
Comparator
Aortic systolic blood pressure and aortic augmentation index obtained from carotid and radial arteries with the use of transfer functions.
O
Outcome
Correlation between aortic augmentation index and radial augmentation index obtained without use of a transfer function.surrogate
Main Result
Effect estimate: R=0.96
Central pressure wave reflection can be accurately assessed directly from the radial pulse without the need for a transfer function, questioning the necessity of transfer function-based methods.
Cite This Study
Millasseau et al. (2003) conducted an observational in Healthy volunteers, essential hypertension, and coronary artery disease (n=84). Arterial tonometry vs. Carotid vs radial transfer functions was evaluated on Correlation between aortic augmentation index and radial augmentation index (R=0.96). Direct measurement of the radial augmentation index without a transfer function closely correlated with the aortic augmentation index (R=0.96), questioning the need for transfer functions.