What question did this study set out to answer?

Summarize ethnicity-related differences in response to oral antithrombotic therapy in cardiovascular disease and highlight the need for tailored regimens in East Asian populations.

January 1, 2020Korean Circulation JournalOpen Access

Ethnic Differences in Oral Antithrombotic Therapy

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Why the study?

Reports suggest ethnic differences in therapeutic requirements and responses to oral antithrombotic therapy, with East Asians showing lower ischemic and higher bleeding outcomes compared to Westerners.

Does oral antithrombotic therapy have different therapeutic requirements and responses in East Asians compared to Westerners with cardiovascular disease?

Key Points

Summarize ethnicity-related differences in response to oral antithrombotic therapy in cardiovascular disease and highlight the need for tailored regimens in East Asian populations.
Narrative review evaluating therapeutic requirements and clinical responses to antiplatelet and anticoagulation therapies across ethnic groups.
Comparative synthesis assessing ischemic and bleeding outcome distributions between East Asian and Western cohorts.
East Asian patients exhibit a distinct risk profile featuring a lower incidence of ischemic events alongside a higher incidence of bleeding complications relative to Western populations.
Identified ethnic variations support the development of individualized, population-specific antithrombotic regimens rather than universal treatment paradigms.

Structured PICO

Does oral antithrombotic therapy have different therapeutic requirements and responses in East Asians compared to Westerners with cardiovascular disease?

Population

Patients with cardiovascular (CV) disease, with a focus on East Asians compared to Westerners

Intervention

Oral antithrombotic therapy (antiplatelet therapy and anticoagulation therapy)

Outcome

Ischemic outcomes and bleeding outcomes

This review highlights the need for a more effective and targeted antithrombotic treatment strategy in East Asians due to their unique risk profile of lower ischemic and higher bleeding outcomes compared to Westerners.

Discussion

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Implication

May inform ethnicity-specific antithrombotic strategies in East Asians; leaves open confirmation via dedicated RCTs.

Cite This Study

Cho et al. (2020) studied this question.

synapsesocial.com/papers/6a10594f8090e499da6103eb https://doi.org/10.4070/kcj.2020.0098

Topics

Dual antiplatelet therapy Anticoagulation in AF

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Ethnic Differences in Oral Antithrombotic Therapy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Ethnic Differences in Oral Antithrombotic Therapy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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