Key result
Darusentan significantly reduced diastolic blood pressure compared to placebo at the 100 mg dose (mean difference -8.3 mm Hg; 95% CI -11.1 to -5.5; P=0.0001) in patients with hypertension.
Why the study?
Does darusentan reduce blood pressure in patients with hypertension?
Population
392 patients with hypertension, baseline average blood pressure 168.27/103.49 mm Hg.
Comparison
Darusentan 10 mg, 30 mg, or 100 mg for 6 weeks vs Placebo for 6 weeks
Design
RCT, randomized, parallel-group, double-blind
Follow-up
6 weeks
Authors
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Darusentan offers a novel antihypertensive mechanism; confirms selective endothelin A antagonism in an RCT.
RCT (n=392)
Double-blind
parallel-group
Yes
Does darusentan reduce blood pressure in patients with hypertension?
Effect estimate: Mean difference -8.3 mm Hg (100 mg dose) (95% CI -11.1, -5.5)
p-value: p=.0001
Darusentan, a selective endothelinA receptor antagonist, significantly reduces systolic and diastolic blood pressure in a dose-dependent manner in patients with hypertension.
Nakov et al. (2002) conducted an RCT in Hypertension (n=392). Darusentan vs. Placebo was evaluated on Diastolic blood pressure reduction (Mean difference -8.3 mm Hg (100 mg dose), 95% CI -11.1, -5.5, p=.0001). Darusentan significantly reduced diastolic blood pressure compared to placebo at the 100 mg dose (mean difference -8.3 mm Hg; 95% CI -11.1 to -5.5; P=0.0001) in patients with hypertension.
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