Key result
Increases in contraction frequency from 0.2 to 300 beats/min decreased time to peak tension by 40% and relaxation time by 49%, while increasing maximum rate of tension development by 560%.
Why the study?
Does contraction frequency alter the strength and time course of contraction in isolated cat papillary muscles?
Population
40 isometrically contracting, isolated cat papillary muscles (cylindrical, radius <0.43 mm) at 38 C
Design
Preclinical
Authors
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Supports frequency effects on contractility in isolated muscle; leaves open human in vivo translation.
Does contraction frequency alter the strength and time course of contraction in isolated cat papillary muscles?
Changes in heart rate significantly alter both the degree of activation and the duration of the active state of contractile elements in mammalian ventricular muscle.
Jan Koch‐Weser (1963) studied Normal physiology (papillary muscle contraction) (n=40). Changes in frequency of contraction was evaluated on Development of tension and time course of contraction. Increases in contraction frequency from 0.2 to 300 beats/min decreased time to peak tension by 40% and relaxation time by 49%, while increasing maximum rate of tension development by 560%.
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