Key result
Elevated serum cholesterol level (highest vs lowest quartile) was an independent predictor of coronary heart disease risk in men aged 65 years and older (RR 1.64; 95% CI 1.14 to 2.36).
Why the study?
Does elevated serum cholesterol level increase the risk of coronary heart disease in men aged 65 years and older?
Population
1,480 men aged 65 years and older, free of coronary heart disease, from the Honolulu (Hawaii) Heart Program
Comparison
Highest quartile of serum cholesterol level vs Lowest quartile of serum cholesterol level
Design
Cohort
Follow-up
average of 12 years
Authors
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Association persists in men ≥65; extends evidence to older populations but leaves open treatment implications.
Cohort (n=1,480)
No
Does elevated serum cholesterol level increase the risk of coronary heart disease in men aged 65 years and older?
Effect estimate: RR 1.64 (95% CI 1.14 to 2.36)
Elevated serum cholesterol remains an independent predictor of coronary heart disease in men older than 65 years, suggesting lipid evaluation is still warranted in the elderly.
Richard Benfante (1990) conducted a cohort in Coronary heart disease (n=1,480). Elevated serum cholesterol level (highest quartile) vs. Lowest quartile of serum cholesterol level was evaluated on Incidence of coronary heart disease (RR 1.64, 95% CI 1.14 to 2.36). Elevated serum cholesterol level (highest vs lowest quartile) was an independent predictor of coronary heart disease risk in men aged 65 years and older (RR 1.64; 95% CI 1.14 to 2.36).
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