What does this research mean for the field?

Physical training improves cardiac pumping performance through enhanced ventricular muscle function, specifically characterized by faster relaxation, rather than through changes in end-diastolic volume. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to assess the effects of physical training on cardiac function and end-diastolic volume in isolated rat hearts.

May 1, 1977Circulation Research

Effects of physical training on end-diastolic volume and myocardial performance of isolated rat hearts.

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Why the study?

Does physical training improve ventricular muscle performance and cardiac function in isolated rat hearts?

Population

Isolated hearts from rats

Comparison

Physical training (swimming) vs Sedentary rats

Design

Preclinical

Authors

MBMalcolm BersohnElectrophysiology JSJ. ScheuerAlbert Einstein College of Medicine

Discussion

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Implication

Training may enhance intrinsic rat heart performance; extends preclinical data but leaves human translation open.

Key Points

The aim was to assess the effects of physical training on cardiac function and end-diastolic volume in isolated rat hearts.
Compared cardiac performance of swimming-conditioned (CH) and sedentary (SH) rats in an isolated heart apparatus.
Measured aortic flow, left ventricular pressure, oxygen consumption, and varied atrial filling pressure from 5 to 20 cm H2O.
Ejection fraction, peak aortic flow, and cardiac output were significantly greater in CH than in SH, with differences increasing at higher atrial pressures.
Maximal negative dP/dt was higher in CH than SH at all preloads (P < 0.001).
Oxygen consumption in CH increased proportionally with the work done.

Structured PICO

Does physical training improve ventricular muscle performance and cardiac function in isolated rat hearts?

Population

Isolated hearts from rats

Intervention

Physical training (swimming)

Comparator

Sedentary rats

Outcome

Ventricular muscle performance and cardiac function (including ejection fraction, circumferential fiber velocity, peak systolic pressure, peak aortic flow, cardiac output, stroke work, and maximal negative dP/dt)surrogate

Physical training improves pumping performance and relaxation in isolated rat hearts, indicating a direct change in ventricular muscle function.

Cite This Study

Bersohn et al. (1977) studied this question.

synapsesocial.com/papers/6a1098f2e1a472cb5efd329b https://doi.org/10.1161/01.res.40.5.510

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Effects of physical training on end-diastolic volume and myocardial performance of isolated rat hearts.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of physical training on end-diastolic volume and myocardial performance of isolated rat hearts.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider